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Yoga is an ancient behavioral practice that allows for the development of the skills of mind-body awareness or mindfulness, self-regulation of internal physiological and psychological state, and physical fitness. Yoga is becoming increasingly popular as a behavioral strategy for the promotion and maintenance of health and wellness, as preventive medicine, and also as an adjunct therapeutic intervention. Application of yoga interventions provide psychophysiological and clinical outcomes that are not currently readily available within the repertoire of modern medicine, including improvements in physical flexibility and self-efficacy, respiratory function, stress reduction and coping, resilience to stress, emotion regulation, mind-body awareness and mindfulness, subjective well-being, quality of life, and life meaning and purpose. This presentation will overview the scientific evidence on the underlying mechanisms of yoga practice supporting the rationale for these applications of yoga, and will also review the published clinical trial evidence for its efficacy in wellness, prevention and therapy. Question and answer session will follow.